一、个人简介
杨晶,女,1988年10月出生,博士、副研究员。
主要经历:
2018.8至今 江南大学生命科学与健康工程学院,助理研究员
2017.7-2018.7东部战区总医院,助理研究员
2014.5-2016.4美国Virginia Commonwealth University,访问学者
2011.9-2017.6中国药科大学,博士
2007.9-2011.6安徽中医药大学,本科
二、研究领域
1.肝脏损伤与修复的机制研究及药物干预
2.重症胰腺炎、脓毒症等重症炎症性疾病的分子网络调控
3.天然活性物质筛选及分子机制
三、学术成果
(一)代表性项目
[1]国家自然科学基金青年基金项目,81900560,主持;
[2]江苏省自然科学基金青年项目,BK20180294,主持;
[3]中国博士后科学基金第67批面上资助,2020M671348,主持;
[4]无锡市科技发展医疗卫生指导性计划,主持;
[5]企业横向课题多项。
(二)代表性论文
[1]Jing Yang, Xujiao Tang, Zhu Liang,et al. Taurocholic Acid Promotes Hepatic Stellate Cell Activation via S1PR2/p38 MAPK/YAP Signaling under Cholestatic Conditions, Clinical and Molecular Hepatology.2023.
[2]Jing Yang, Xujiao Tang, Baiqiang Li,et al. Sphingosine 1-phosphate receptor 2 mediated early stages of pancreatic and systemic infammatory responses via NF-kappa B activation in acute pancreatitis. Cell Communication and Signaling, 2022, 20:157-168.
[3]Jing Yang, Xujiao Tang, Qingqing Wu,et al. Heparin Protects Severe Acute Pancreatitis by Inhibiting HMGB-1 Active Secretion from Macrophages. Polymers, 2022, 14: 2470-2483.
[4]Jing Yang, Xujiao Tang, Qingqing Wu,et al. A Severe Acute Pancreatitis Mouse Model Transited from Mild Symptoms Induced by A “Two-Hit” Strategy with L-Arginine. Life, 2022, 12, 126-137.
[5]Jing Yang, Xujiao Tang, Xue Ke,et al. Triptolide Suppresses NF-κB-Mediated Inflammatory Responses and Activates Expression of Nrf2-Mediated Antioxidant Genes to Alleviate Caerulein-Induced Acute Pancreatitis. International Journal of Molecular Sciences.2022, 23: 1252-1265.
[6]杨晶,刘晓妮,吴青青,等.6 -O-脱硫酸化肝素通过Syndecan-1 / c -Met / Akt途径延缓博来霉素诱导的肺损伤.中国药理学通报.2022,38(8):1147-1155.
[7]Jing Yang, Yiwen Zhou, Jinsong Shi. Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK. Life Sciences. 2020,251:117645.
[8]杨晶,倪佳良,高越颖.蛹虫草虫草素对ANIT诱导胆汁淤积性肝损伤的保护作用[J].菌物学报.2020,40 (2):1-9
[9] Yongqing Wang#, Hiroaki Aoki#,Jing Yang#,et al. The role of S1PR2 in bile acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice, Hepatology, 2017, 65(6): 2005-2018.
[10]Jing Yang, Lixin Sun, Lu Wang,et al. Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats, Frontiers in pharmacology, 2017, 8: 260.
[11]Jing Yang, Yunzhou Li, Phillip Hylemon,et al. Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation, Biomedicine & Pharmacotherapy, 2017, 95: 1777-1788.
(三)代表性专利
[1]肝素及其衍生物在预防和治疗肝衰竭中的应用.2023,中国,CN202310200058.X.
[2]一种抗纤维化的化合物.2023,中国,CN202310200267.4.
[3]一种肝素类似物在制备治疗或预防急性胰腺炎药物中的应用.2022,中国,CN202110527675.1.
四、联系方式
通讯地址:江苏省无锡市蠡湖大道1800号江南大学生命科学与健康工程学院
邮编:214122
邮箱:yangjing@jiangnan.edu.cn
【以上资料更新日期】:2023年9月