一、个人简介

张燕，女，1986年5月出生，研究员，博士生导师，江苏省药学会海洋药物专业委员会委员，中国化学会会员，Advanced Functional Materials, International Journal of Biological Macromolecules,Macromolecular Bioscience等期刊审稿人。

主要经历：

2004.9-2008.6 中南大学，药学，学士

2008.9-2009.6 中国药科大学，药物化学，研究生学习

2009.9-2013.8 瑞典皇家理工学院，有机化学，博士

2013.8-2013.11 瑞典皇家理工学院，有机化学，博士后兼有机合成实验课教学

2014.7-2014.9 新加坡国立大学，有机化学，博士后

2014.11-2017.10 法国国家科学研究中心-欧洲膜技术研究所，博士后

2017.11-2021.12 江南大学药学院，研究员

2018.9-2018.12 美国马萨诸塞大学洛厄尔分校访问教授

2022.1-至今 江南大学生命科学与健康工程学院，研究员

二、研究领域

主要研究方向是药剂学与生物医用材料，基于天然/合成高分子，开发新型智能纳米/水凝胶材料，用于疾病的诊断与治疗。近年来主持国家自然科学基金、江苏省自然科学基金，荣获江苏省特聘教授、“双创”博士荣誉称号，以第一或通讯作者发表SCI文章40余篇，包括专业权威期刊Science Advances、Chemical Reviews、ACS Catalysis、Bioactive Materials、ACS Applied Materials & Interfaces等，并参与本科与研究生教学。

三、荣誉奖励

江苏特聘教授（2020）

江苏省“双创”博士（2018）

全国大学生生命科学竞赛（2024，科学探究类）全国三等奖，指导老师

全国大学生生命科学竞赛（2025，科学探究类）全国三等奖，指导老师

四、学术成果

（一）代表性项目

江苏省自然科学基金青年项目，2018-2021，主持

国家自然科学基金青年项目，2020-2023，主持

校企合作项目—新型高分子骨科材料开发（2022-2026），主持

中央高校自主科研计划青年基金（2018-2019），主持

（二）代表性论文

[1] Rui Wang, Shang Wang, Jinghua Chen, Yan Xu, Xiaowei Yu,* Mihail Barboiu,*Yan Zhang,*Enhanced activity and self-regeneration in dynameric cross-linked enzyme nano-aggregates,Sci. Adv.2025, 11: eads9371 (IF: 12.5)

[2] Jun Wu, Jing Liang, Sichen Li, Jinjin Lu, Yi Li, Bin Zhang, Min Gao, Juan Zhou,Yan Zhang,* Jinghua Chen,* Cancer vaccine designed from homologous ferritin-based fusion protein with enhanced DC-T cell crosstalk for durable adaptive immunity against tumors,Bioact. Mater.2025, 46: 516-530 (IF: 20.3)

[3] Jun Wu, Jing Liang, Sichen Li, Jinjin Lu, Juan Zhou, Min Gao,Yan Zhang,* Jinghua Chen,* DNA nanovaccines derived from ferritin-modified glycogens for targeted delivery to immature dendritic cells and for promotion of Th1 cell differentiation,Acta Biomater.2025, 196: 436-452 (IF: 9.6)

[4] Jun Wu, Tiantian Tan, Jinghua Chen,*Yan Zhang,* pH-Responsive conformational-switching cationic fusion protein for promoted plasmid DNA delivery and transfection,Biomacromolecules2025, 26(3): 1788-1798 (IF: 5.4)

[5] Sichen Li, Difei Zhang, Yi Li, Jingjing Zhou, Jinghua Chen,*Yan Zhang,* All-in-one multifunctional tri-block glycopolymers for targeted delivery of cisplatin and cancer chemotherapy,Colloid Surface B2025, 252:114639 (IF: 5.6)

[6] Yan Zhang,* Yi Li, Jieyu Gu, Jun Wu, Yongxin Ma, Guodong Lu, Mihail Barboiu,* Jinghua Chen,* Glycopolymeric micellar nanoparticles for platelet-mediated tumor-targeted delivery of docetaxel for cancer therapy,ACS Appl. Mater. Interfaces2024.16: 44528-44537 (IF: 8.2)

[7] Bin Zhang, Jingjing Zhou, Yuanyuan Li, Jinghua Chen,*Yan Zhang,* Bioactive modification of cyclic olefin copolymer (COC) film surfaces by hyaluronic acid and chitosan for enhanced cell adhesion,Int. J. Biol. Macromol.2024.281: 136169 (IF: 8.5)

[8] Baotong Ye, Guodong Lu, Jingjing Zhou, Yi Li, Yongxin Ma,Yan Zhang,* Jinghua Chen,* Sulfated glyco-based hydrogels as self-healing, adhesive, and anti-inflammatory dressings for wound healing,Colloid Surface B2024, 238: 113915 (IF: 5.6)

[9] Jieyu Gu, Yi Li, Guodong Lu, Yongxin Ma,Yan Zhang,* Jinghua Chen,* Glycopolymer-grafted nanoparticles as glycosaminoglycan mimics with cell proliferation and anti-tumor metastasis activities,Int. J. Biol. Macromol .2023.253: 126975 (IF: 8.5).

[10] Baotong Ye, Yongxin Ma, Difei Zhang, Jieyu Gu, Ziyan Wang,Yan Zhang,*Jinghua Chen,*Glycopolymer-based antiswelling, conductive, and underwater adhesive hydrogels for flexible strain sensor application,ACS Biomater. Sci. Eng.2023, 9(12): 6891-6901 (IF: 5.5)

[11] Baotong Ye, Zhi Cai, Qimeng Wang,Yan Zhang,* Jinghua Chen,* Supramolecular self-assembly of glycosaminoglycan mimetic nanostructures for cell proliferation and 3D cell culture application,Int. J. Biol. Macromol.2023, 231: 123179. (IF: 8.5)

[12] Ziyan Wang, Jieyu Gu, Difei Zhang,Yan Zhang,* Jinghua Chen,* Structurally dynamic gelatin-based hydrogels with self-healing, shape memory, and cytocompatible properties for 4D printing,Biomacromolecules2023, 24: 109. (IF: 5.4)

[13] Qimeng Wang, Ziyan Wang, Difei Zhang, Jieyu Gu, Yongxin Ma,Yan Zhang,* Jinghua Chen,* Circular patterns of dynamic covalent hydrogels with gradient stiffness for screening of the stem cell microenvironment,ACS Appl. Mater. Interfaces2022, 14: 47461. (IF: 8.2)

[14] Zhi Cai, Yishu Yan, Juan Zhou, Yang Yang,Yan Zhang,* Jinghua Chen,* Multifunctionalized brush-like glycopolymers with high affinity to P-selectin and antitumor metastasis activity,Biomacromolecules2021, 22: 1177. (IF: 5.4)

[15]Yan Zhang, Mihail Barboiu*, Olof Ramstrom*, Jinghua Chen*. Surface-directed selection of dynamic constitutional frameworks as an optimized microenvironment for controlled enzyme activation.ACS. Catal.2020, 10: 1423. (IF: 13.1)

[16]Yan Zhang*, Yunchuan Qi, Sebastien Ulrich*, Mihail Barboiu*, Olof Ramstrom*. Dynamic covalent polymers for biomedical applications.Mater. Chem. Front.2020, 4: 489. (IF: 6.4)

[17]Yan Zhang*, Yang Zhang, Olof Ramstrom*. Dynamic covalent kinetic resolution.Catal. Rev.2020, 62: 66. (IF: 10.1)

[18] Yi Liu, Zhujie Xu, Qiqi Wang, Yuyu Jiang, Rui Wang, Shayang Chen, Jingyu Zhu,Yan Zhang*, Jinghua Chen*. Selective regulation of RANKL/RANK/OPG pathway by heparan sulfate through the binding with estrogen receptor β in MC3T3-E1 cells.Int. J. Biol. Macromol.2020, 161: 1526. (IF: 8.5)

[19] Yi Liu, Rui Wang, Shayang Chen, Zhujie Xu, Qiqi Wang, Peng Yuan, Yiyi Zhou,Yan Zhang*, Jinghua Chen*. Heparan sulfate loaded polycaprolactone-hydroxyapatite scaffolds with 3D printing for bone defect repair.Int. J. Biol. Macromol.2020, 148: 153. (IF: 8.5)

[20]Yan Zhang, Mihail Barboiu*. Constitutional dynamic materials - towards natural selection of function.Chem. Rev.2016, 116: 809. (IF: 55.8)

（三）授权专利

[1]陈敬华，张燕，叶宝彤，一种基于含糖聚合物的高性能水下粘合凝胶及其制备方法，授权号：ZL 202110863259.9

[2]张燕，陈敬华，顾婕妤，叶宝彤，张涤非，王紫嫣，一种血小板靶向含糖聚合物胶束纳米粒及其制备方法，授权号：ZL 202310064944.4

五、联系方式

通讯地址：江苏省无锡市蠡湖大道1800号江南大学生命科学与健康工程学院

邮编：214122

邮箱：zhangyanyz@jiangnan.edu.cn