Personal Information

Name: Shijin Song

Degree: Ph.D.

Position: Professor, Ph.D. Supervisor

Director: Jiangsu Engineering Research Center for Biopharmaceutical Manufacturing

Deputy Director: National and Local Joint Engineering Research Center for Microorganisms on the Qinghai-Tibet Plateau

Leader: National Virtual Simulation Experimental Teaching Center for Biopharmaceuticals

Academic Background

2010-present Professor, Ph.D. Supervisor, School of Life Science and Health Engineering, Jiangnan University

1993-2010 Researcher and Director of Science and Technology Department, Nanjing Institute of Wild Plants Comprehensive Utilization

2002-2005 Ph.D. in Fermentation Engineering, Jiangnan University

1989-1993 B.S. in Fermentation Engineering, Wuxi Light Industry Institute

Areas of Expertise

Development of green manufacturing processes for pharmaceutical chemicals and drugs; isolation, preparation, and functional evaluation of bioactive substances; discovery, screening, and application of biocatalysts.

Awards

1. Key Technology Research and Industrial Application of Chitosan Resource Bioprocessing and Lean Preparation, Second Prize of Jiangsu Provincial Science and Technology Award, 2020 (Rank 1).

2. Key Technology and Industrial Application of Green Manufacturing of Plant-Derived Aminosugars, Third Prize of Jiangsu Provincial Science and Technology Award, 2018 (Rank 3).

3. Key Technology and Industrialization of Plant-Derived Aminosugar Preparation Based on Biotransformation and Membrane Spectrum Technology, First Prize of China Business Federation Science and Technology Award, 2017 (Rank 1).

4. Design of Non-sterile Bulk Drug Workshop, First Prize of the 6th "National Pharmaceutical Engineering Cup" National University Pharmaceutical Engineering Design Competition, Advisor.

5. Research and Application of Key Technologies for Deep Processing of Functional Chitosan, Second Prize of Jiangsu Provincial Science and Technology Award, 2011 (Rank 4).

6. Development of Key Technologies for Functional Amino Acids and Their Derivatives Produced by Fermentation in Food Biotechnology, First Prize of China Food Industry Association Science and Technology Award, 2011 (Rank 5).

7. New Technology and Product Application of Polymer Polysaccharide Biomass Processing, Second Prize of National Technical Invention Award, 2011 (Rank 5).

8. Key Technology and Industrial Application of Microbial Community Functional Optimization in the Brewing of Zhenjiang Vinegar, First Prize of Jiangsu Provincial Science and Technology Award, 2014 (Rank 4).

Representative Projects

1. Deconstruction of Reductive Function of Keratinase and Its Catalytic Specificity Multisite Evolution (21978116), National Natural Science Foundation of China.

2. Effects and Collaborative Remodeling of BpK9 Keratinase by Leader Peptide (21676121), National Natural Science Foundation of China.

3. Green Separation and Bioreinforcement Technology Industrialization of Dairy Nutrient Components (2020BFH02011), Key Project of Key Research and Development Program of Ningxia Hui Autonomous Region.

4. Research and Industrialization of Plant-Derived Aminosugar Prepared by Biorefinery and Membrane Spectrum Technology (BA2015006), Major Achievement Transformation Project of Jiangsu Province.

5. Key Technology and Application of Preparing Factors for Improving Gastrointestinal Function (2012BAD33B06), National Key Technology Support Program Project.

6. Industrial Development of High-Performance Microbial Keratinase (BE2018622), Key Research and Development Program of Jiangsu Province.

7. Molecular Modification of Industrial Enzymes and Green Bioprocess (2012AA022204C), 12th Five-Year National 863 Project.

8. Key Technology Development and Scale Demonstration of Comprehensive Utilization of Low-Value Shellfish Along the Jiangsu Coast (201305007), National Oceanic Administration Public Welfare Special Project.

9. Biological Transformation Technology of Steroids (2011AA02A211), Major Project of National 863 Program,

Publications

[1] Qian Jianying; Gong Jin-Song; Xu Zheng-Hong; Jin Jian*;Shi Jin-Song*; Significant improvement in conversion efficiency of isonicotinic acid by immobilization of cells via a novel microsphere preparation instrument[J]. Bioresource Technology, 2021, 320:124307.

[2] Yang Yang; Wang Song-Tao; Lu Zhen-Ming; Zhang Xiao-Juan; Chai Li-Juan; Shen Cai-Hong;Shi Jin-Song*; Xu Zheng-Hong*; Metagenomics unveils microbial roles involved in metabolic network of flavor development in medium-temperature daqu starter[J]. Food Research International, 2021, 140: 110037

[3] Su Chang; Gong Jin-Song*; Qin Jiufu; Li Heng; Li Hui; Xu Zheng-Hong;Shi Jin-Song*; The tale of a versatile enzyme: Molecular insights into keratinase for its industrial dissemination[J]. Biotechnology Advances, 2020, 45:107655.

[4] Gong Jin-Song; Ye Jin-Peng; Tao Li-Yan; Su Chang; Qin Jiufu; Zhang Yan-Yan; Li Heng; Li Hui; Xu Zheng-Hong;Shi Jin-Song*; Efficient keratinase expression via promoter engineering strategies for degradation of feather wastes[J]. Enzyme and Microbial Technology, 2020, 137:109550.

[5] Zhang Rong-Xian, Gong Jin-Song, Su Chang, Qin Jiufu, Li Heng, Li Hui,Shi Jin-Song*, Xu Zheng-Hong. Recombinant expression and molecular engineering of the keratinase from Brevibacillus parabrevis for dehairing performance[J]. Journal of Biotechnology, 2020, 320: 57-65.

[6] Ye Jin-Peng, Gong Jin-Song*, Su Chang, Liu Yan-Ge, Jiang Min, Pan Huaping, Li Rui-Yi, Geng Yan, Xu Zheng-Hong,Shi Jin-Song*. Fabrication and characterization of high molecular keratin based nanofibrous membranes for wound healing[J]. Colloids and Surfaces B: Biointerfaces, 2020, 194: 111158.

[7] Su Chang, Gong Jin-Song*, Ye Jin-Peng, He Ji-Meng, Li Rui-Yi, Jiang Min, Geng Yan, Zhang Yan, Chen Jing-Hua, Xu Zheng-Hong,Shi Jin-Song*. Enzymatic Extraction of Bioactive and Self-Assembling Wool Keratin for Biomedical Applications [J].Macromolecular Bioscience, 2020, 20 (9):2000073.

[8] Su Chang, Gong Jin-Song*, Qin Jiufu, He Ji-Meng, Zhou Zheng-Chuan, Jiang Min, Xu Zheng-Hong,Shi Jin-Song*. Glutathione enables full utilization of wool wastes for keratin production and wastewater decolorization [J]. Journal of Cleaner Production, 2020, 270: 122092.

[9] Su, Chang; Gong, Jin-Song*; Sun, Yu-Xin; Qin, Jiufu; Zhai, Shen; Li, Heng; Li, Hui; Lu, Zhen-Ming; Xu, Zheng-Hong;Shi, Jin-Song*, Combining Pro-peptide Engineering and Multisite Saturation Mutagenesis To Improve the Catalytic Potential of Keratinase [J]. ACS Synthetic Biology 2019, 8 (2), 425-433.

[10] Chunyu Yan-Jie, Lu Zhen-Ming*, Luo Zhi-Shan, Li Shuo-Shuo, Li Hui, Geng Yan, Xu Hong-Yu, Xu Zheng-Hong,Shi Jin-Song*. Promotion of Metabolite Synthesis in Isaria cicadae, a Dominant Species in the Cicada Flower Microbiota, by Cicada Pupae[J]. Journal of Agricultural and Food Chemistry, 2019, 67: 8476-8484.

[11] Qian Jianying, Wang Xiaomeng, Shu Jie, Su Chang, Gong Jinsong, Xu Zhenghong, Jin Jian*,Shi Jin-Song*. A novel complex of chitosan-sodium carbonate and its properties[J]. Marine Drugs, 2018, 16, 416.

[12] Gong, Jin-Song; Zhang, Qiang; Gu, Bing-Chen; Dong, Ting-Ting; Li, Heng; Li, Hui; Lu, Zhen-Ming;Shi, Jin-Song*; Xu, Zheng-Hong*. Efficient biocatalytic synthesis of nicotinic acid by recombinant nitrilase via high density culture [J].Bioresource Technology, 2018, 260:427-431.

[13] Zheng, Jialin; Li, Heng*; Zhang, Xiaojuan; Jiang, Min; Luo, Chunqin; Lu, Zhenming; Xu, Zhenghong;Shi, Jinsong*. Prebiotic Mannan-Oligosaccharides Augment the Hypoglycemic Effects of Metformin in Correlation with Modulating Gut Microbiota [J].Journal of Agricultural and Food Chemistry, 2018, 66 (23):5821-5831.

[14] Tao, Li-Yan ; Gong, Jin-Song ; Su, Chang ; Jiang, Min ; Li, Heng ; Li, Hui; Lu, Zhen-Ming; Xu, Zheng-Hong;Shi, Jin-Song*. Mining and expression of a metagenome-derived keratinase responsible for biosynthesis of silver nanoparticles [J].ACS Biomaterials Science & Engineering, 2018, 4 (4):1307-1315.

[15] Su Chang, Gong Jin-Song, Zhang Rong-Xian, Tao Li-Yan, Dou Wen-Fang, Zhang Dan-Dan, Li Heng, Lu Zhen-Ming, Xu Zheng-Hong,Shi Jin-Song*. A novel alkaline surfactant-stable keratinase with superior feather-degrading potential based on library screening strategy [J].International Journal of Biological Macromolecules2017, 95: 404–411

[16] Li Li, Li Heng, Qian Jianying, He Yongfeng, Zheng Jialin, Lu Zhenming, Xu Zhenghong,Shi Jin-Song*. Structural and immunological activity characteri -zation of a polysaccharide isolated from Meretrix meretrix Linnaeus [J].Marine Drugs2016, 14(1): 6.

[17] Liu Heng-Xia, Gong Jin-Song, Li Heng, Lu Zheng-Ming, Li Hui, Qian Jian-Ying, Xu Zheng-Hong,Shi Jin-Song*. Biochemical characterization and cloning of an endo-1, 4-β-mannanase from Bacillus subtilis YH12 with unusually broad substrate profile [J].Process Biochemistry2015, 50 (5): 712-721.

Patents

[1]Shi Jinsong, Xu Zhenghong, Zhang Chao, Gong Jinsong, Li Heng, Ding Zhenzhong, Fang Xiang, Zhang Wanhong. Directed modification of glucosamine synthase mutant and application thereof. US10233439B2, Date of Patent: 2019.03.19.

[2]Jinsong Shi; Jinsong Gong; Liyan Tao; Zhenghong Xu; Chang Su. A promoter for heterologous expression of keratinase and its application, Patent No. 2018109334167, China, Authorized on June 23, 2020.

[3]Jinsong Shi; Zhenghong Xu; Heng Li; Yao Hao; Jinsong Gong; Hui Li. Recombinant alginate lyase and its construction method and application, Patent No. 2018103254879, China, Authorized on June 09, 2020.

[4]Jinsong Shi; Zhenghong Xu; Jinsong Gong; Haijuan Hou; Xiaomei Zhang; Heng Li. Recombinant strain expressing phospholipase D and its application, Patent No. 2018108448601, China, Authorized on June 05, 2020.

[5]Jinsong Shi; Jinsong Gong; Rongxian Zhang; Zhenghong Xu; Heng Li; Wenfang Dou; Zhenming Lu; Dandan Zhang. Aspergillus keratinase and its fermentation and application methods, Patent No. 2015110267210, China, Authorized on March 08, 2019.

[6]Jinsong Shi; Zhenghong Xu; Yan Geng; Jinsong Gong; Jianying Qian. PCR detection technology of allergenic substances from chitin in amino sugar products, Patent No. 2015104827855, China, Authorized on January 16, 2018.

[7]Jinsong Shi; Tao Yang; Heng Li; Jianying Qian; Guoxiang Qi; Xiangdong Ju. Method for extracting residual materials using shrimp shell enzyme to prepare highly adsorbent biological materials, Patent No. 201410244356X, China, Authorized on July 11, 2017.

[8]Jinsong Shi; Min Jiang; Zhenghong Xu; Jianying Qian; Zhenming Lu. Sustained-release excipient for improving the stability of the main drug, Patent No. 2014106776745, China, Authorized on June 23, 2017.

[9]Jinsong Shi; Zhenghong Xu; Dafeng Sun; Zhiqiang Liu; Wei Cong; Shanlong Qi; Chao Zhang; Zhenzhong Ding. Method for preparing active peptide powder and chitosan from by-products of shrimp and crab, Patent No. 2014100360204, China, Authorized on May 11, 2016.

[10]Jinsong Shi; Yue Wang; Zhenghong Xu; Xiaomei Zhang; Dandan Zhang. Bacillus subtilis strain producing keratinase and its application method, Patent No. 2013106710654, China, Authorized on January 27, 2016.