Professor of theSchool of Life Sciences and Health Engineering, Jiangnan University
Email: zhaoqiyang@jiangnan.edu.cn
Education and Professional Experiences
Dr. Yang received hisPh.D. degree in the Division of Chemistry and Biological Chemistry at Nanyang Technological University (NTU) supported by a research scholarship provided by NTU.After he earned his Ph.D.degree, he worked asa postdoctoral fellowin the Division of Chemistry and Biological Chemistry atNTU in 2012.From Nov to Dec in 2012, he worked as visiting scholar inHong Kong University of Science and Technology.In Jan 2013, he joined the facultyas associate professorin the School Food Science and Technology at Jiangnan University.From Jan 2017, he transferred to School of Pharmaceutical Sciences in same university. He got promoted to full Professor in 2020. Form Jan 2023, School of Pharmaceutical Sciences has renamed School of Life Sciences and Health Engineering.
Research Achievements
The major focuses ofhisresearch ischemical biology with emphasis on the DNA structure and function. Most importantly, he has discovered that Human topoisomerase I could recognize the forcible curvature of DNA, which is one of the greatest breakthroughs in the field of topoisomerase.In addition, he is a member of Royal Society of Chemistry and Chinese Chemical Society, and the principle investigator on Natural Science Foundation of China Grant, the Grant for the Returned Overseas Scholars of Ministry of Education and so on, as well as the referee for some journals related to chemistry and pharmaceutical sciences,includingJACS, ACS Appl. Mater. Interfaces,Acta Biomaterialiaand so on.
ResearchInterests
Nucleic acid drug
DNA structure and function
Nucleic acidnano-biotechnology
Drug delivery
Awarded Research Grants
1.Fok Ying-Tong Education Foundation
2.Six talent peaks project in Jiangsu Province
3.The Key Project for the Scientific and Technological Activities of Returned Overseas Chinese Scholar in Wuxi
4.Natural Science Foundation of China
5.Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
6.Jiangsu Province Doctoral Research Plan for the Talent form World's Famous Universities
7.Natural Science Foundation of Jiangsu Province
8.Fundamental Research Funds for the Central Universities
Selected Publications
1.Wu, H.; Ding, X.F.; Chen, Y.;Cai, Y.F.;Yang, Z.Q.*; Jin, J.*EGFR-targeted humanized single chain antibody fragment functionalized silica nanoparticles for precision therapy of cancer.Int. J. Biol. Macromol., 2023, 253, 127538.
2.Liu, K.D.; Chen, Y.;Yang, D.T.;Cai, Y.F.;Yang, Z.Q.*; Jin, J.*Betaine-Based and Polyguanidine-Inserted Zwitterionic Micelle as a Promising Platform to Conquer the Intestinal Mucosal Barrier.ACS Appl. Mater. Interfaces,2023, 15, 44, 51650-51662.
3.Liu, K.D.; Chen, Y.;Yang, D.T.;Cai, Y.F.;Yang, Z.Q.*; Jin, J.*Glu-derived Zwitterionic Micelles Conquering the Intestinal Mucosal Barrier toward Oral Delivery.ChemNanoMat, 2023, e202300324.
4.Shen, Y.X.; Zhang, Y.; Gao, X.Y.; Shang, M.D.;Cai, Y.F.;Yang, Z.Q.*MicroRNA functional metal-organic framework nanocomposite for efficient inhibition of drug-resistant breast cancer cells.Emergent Mater, 2023, 6, 1537-1547.
5.Qian, Y.; Han Z.Y.; Yang, D.T.;Cai, Y.F.; Jin, J.*;Yang, Z.Q.*Metal-Organic Frameworks Facilitate Nucleic Acids for Multimode Synergistic Therapy of Breast Cancer.Langmuir, 2023, 39, 8205-8214.
6.He, L,; Shang, M.D.; Chen, Z.K.;Yang, Z.Q.*Metal-Organic Frameworks Nanocarriers for Functional Nucleic Acid Delivery in Biomedical Applications.Chem. Rec., 2023,e202300018.
7.Liu, K.D.; Chen, Y.;Yang, Z.Q.*; Jin, J.*Zwitterionic Pluronic analog-coated PLGA nanoparticles for oral insulin delivery.Int. J. Biol. Macromol., 2023, 236, 123870.
8.Han, Z.Y.;Qian, Y.; Gao, X.Y.; Yang, D.T.;Cai, Y.F.; Chen, Y.; Jin, J.*;Yang, Z.Q.*Hypoxia-responsive covalent organic framework by single NIR laser-triggered for multimodal synergistic therapy of triple-negative breast cancer.Colloid Surface B,2023, 222, 113094.
9.Li, S.; Tian, M.T.; Cai, Y.F.; Jin, J.*;Yang, Z.Q.*Functional Human Serum Albumin as a Dual Phototherapeutic Nanoplatform for Triple-negative Breast Cancer Therapy and Inhibits Metastasis.ChemNanoMat, 2022, e202200452.
10.Chen, W.X.;Li, S.; Shen, Y.X.;Cai, Y.F.; Jin, J.*;Yang, Z.Q.*Polyethylenimine modified graphene oxide for effective chemo-gene-photothermal triples therapy of triple-negative breast cancer and inhibits metastasis.J. Drug Deliv. Sci. Tec., 2022, 74,103521.
11.Li, S.; Kang, Y.;Shang, M.D.;Cai, Y.F.;Yang, Z.Q.*Highly sensitive and selective detection of Ochratoxin a using modified graphene oxide-aptamer sensors as well as application.Microchem. J,2022, 179, 107449.
12.Gong, S.Y.;Shang, M.D.; Li, D.W.;Cai, Y.F.; Jin, J.*;Yang, Z.Q.*Functionalized ZIF-90 for gene-mediated chemotherapy to ameliorate drug resistance in breast cancer.ChemNanoMat, 2022, 8(2), e202100389.
13.Li, Q.X.; Kang, Y.;Yin, S.X.;Qian, Y.;Cai, Y.F.;Yang, Z.Q.*Graphene oxide synergy with the conjugation of DNA and quantum dots for the sensitive detection of Ochratoxin A.Food Anal. Method,2022, 15, 440-447.
14.Shang, M.D.; Wu, Y.Y.; Wang, Y.Y;Cai, Y.F.; Jin, J.*;Yang, Z.Q.*Dual antisense oligonucleotide targeting miR-21/miR-155 synergize photodynamic therapy to treat triple-negative breast cancer and inhibit metastasis.Biomed. Pharmacother., 2022, 146, 112564.
15.Qin, L.;Yang, D.T.; Yin, S.X.;Qian, Y.; Cai, Y.F.; Jin, J.; Huang, G.;*Yang, Z.Q.*Graphene Oxide Biosensors Based on Hybridization Chain Reaction Signal Amplification for Detecting Biomarkers of Radiation-Resistant Nasopharyngeal Carcinoma and Imaging in Living Cells.Langmuir, 2021, 37, 9664-9672.
